CD4+ cells treated with DNA methylation inhibitors induce autologous B cell differentiation.
نویسندگان
چکیده
The DNA methylation inhibitor 5-azacytidine induces autoreactivity in cloned CD4+ T cells, but the functional consequences of this response are unknown. We now report that CD4+ T cells treated with 5-azacytidine respond to autologous antigen-presenting cells and induce autologous B cell differentiation without exogenous antigen or mitogen. This mechanism could play a role in some autoimmune diseases characterized by T cell DNA hypomethylation and polyclonal B cell activation.
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عنوان ژورنال:
- Clinical immunology and immunopathology
دوره 55 3 شماره
صفحات -
تاریخ انتشار 1990